Endocrine Abstracts

Objective: Thermal ablations (TA) are gaining ground as alternative options to conventional therapies for symptomatic benign thyroid nodules. Little is known on the impact of nodule biology on the outcomes of TA. The aim of our study was evaluating the baseline immunocytochemistry profile of thyroid nodules that are poorly responsive to TA, in order to identify potential predictors of treatment response.Methods: we retrospectively selected by propensity ...

Introduction: Radioiodine (RAI) is used as a definitive therapy of hyperthyroidism due to toxic adenoma (TA) as well as toxic multinodular goiter (TMG). Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 666 patients – 484 with TA and 182 with TMG (85.58% of women), aged 56.19±13.88 years. We analyzed retrospectively hormonal and imaging findings (scintigraphy, ultrasonography), ...

Several levo-thyroxine (L-T4) formulations are now available. However, scientific societies discourage the use of generic L-T4 owing to its uncertain bioavailability in comparison with brand L-T4. Recent literature data suggest that using a liquid formulation of brand L-T4 improves the management of hypothyroidism. However, it is not clear whether patient satisfaction improves on liquid (LI) L-T4, as patients may initially...

Background: RAI is used as definitive treatment for hyperthyroidism, but administered activities vary between institutions. We used a fixed activity of RAI therapy for Grave’s disease (GD) and toxic multinodular goitre (TMNG), and calculated activity for toxic adenoma (TA). We reviewed treatment outcomes at one year.Methods: Thyroid function tests 1 year post RAI were reviewed retrospectively to asess outcome for 79 hyperthyroid patients divided int...

Introduction: The reactivation of autoimmune disorders has been described in patients with hypercortisolism after normalization of cortisol secretion. This phenomenon is probably related to the loss of immunosuppressive effect of endogenous glucocorticoids. This is a report of two patients with Takayasu arteritis (TA) and Cushing’s disease (CD), a novel association never described in literature, in whom TA was exacerbated after normalization of cortisol secretion.<p c...

Toxic adenomas (TA) and toxic multinodular goiters (TMNG) are frequent causes of hyperthyroidism in Galicia, an endemic goiter area. In some European countries, 40–80% of toxic goiters are caused by TSH receptor (TSHr) and Gs alfa-subunit (Gsa) mutations that activate cAMP pathway.Aims: To study 1) the prevalence of TSHr and Gsa mutations in TMNG and TA from Galicia, 2) the clonality of sequenced samples, 3) the constitutive activity of the identifi...

Background: Radioiodine(RAI) has been used to treat hyperthyroidism for more than seven decades. Effects of RAI treatment on thyroid function tests(TFT), risk of hypothyroidism, gland and autonomous nodule volumes and on ultrasonographic features in toxic adenoma (TA) and toxic multinodular goitre TMNG patients, have been previously studied by ourselves and other. However, studies evaluating ultrasonographic changes in thyroid and toxic nodule volumes usually have a follow-up ...

Introduction: Utilization rates of fertility preservation among transgender adolescents (TA) are low. Few studies have addressed the reproductive desires of this population. The aim of this study was to assess TA parenthood goals, attitudes about fertility preservation (FP) and perceived barriers to successful gamete banking.Methods: Transgender adolescents who attended the Gender Identity Development Service (GIDS - endocrine clinic) between March and J...

Background: Insulin resistance is the reduced responsiveness of the body to the glucose-lowering activity of insulin. It is usually associated with obesity, but in a minority of patients, this is not the case. Single gene mutations can often be found in such patients, some of which affect the insulin receptor (INSR). There is a spectrum of genetic insulin receptoropathies. These can be considered as two groups. One group comprises rare, severe, autosomal recessive disorders: D...

Introduction: Regulation of adiponectin in GH deficiency (GHD), which presents visceral obesity, is still a matter of debate. No studies have evaluated circulating adiponectin isoforms in adult GHD subjects. Aim of this study was to evaluate total adiponectin (TA) and its isoforms (high molecular weight: HMW, medium molecular weight: MMW, low molecular weight: LMW) in hypopituitary adult subjects with and without GHD, in relation to weight, IGF1 and GH levels.<p class="abs...